2009 T. Franklin Williams Scholar Recipients
Peter M. Abadir, MD
“Age Related Change in Angiotension Receptors and its Contribution to Chronic Inflammation”
Johns Hopkins University School of Medicine
Dr. Peter M. Abadir is Post-Doctoral Fellow in the Division of Geriatric Medicine and Gerontology, Department of Medicine, at the Johns Hopkins University School of Medicine. He is trained in Family Medicine and Internal Medicine-Geriatrics. His main research interests include the effect of aging on receptor crosstalk between Angiostein and Bradykinin receptors; frailty and angiotensin receptors AT1 and AT2; and the regulation of angiotensin receptors. Dr. Abadir obtained his Medical Bachelor and Bachelor of Surgery, and his medical degree from the University of Alfateh in Libya. He completed a family medicine residency at the University of Kentucky College of Medicine, where he was also chief resident. Dr. Abadir then trained at the University of Virginia under a research fellowship in the Endocrine Division, Internal Medicine Department. His T. Franklin Williams project focuses on the study of aging related changes in the renin angiotension system (RAS) and how it influence chronic, late-life inflammation.
2009 T. Franklin Williams Scholar
Peter M. Abadir, MD
Aging is associated with enhanced inflammation. An altered ratio between angiotensin receptors AT1R and AT2R results in induction of inflammation in animal models. The effects of aging on the expression of AT1R and AT2R R in humans and the contribution of changes in AT1R and AT2R to increased inflammation in the older adult have not been previously studied. Our preliminary evidence suggests that frail older adults have up – regulation of AT1R, down – regulation of AT2R expression and implicate for IL6 in this imbalance. We hypothesize that aging is associated with changes in AT1R and AT2R expression in immune system cells and that these changes are driven by age related alterations in D NA methylation of AT1R and AT2R genes. Further we hypothesize that these changes contribute to the increased production of inflammatory cytokines in older individuals which in turn will further heighten the divergence in AT1R and AT2R expression.
The recipient, selected by an academic selection committee composed of nationally prominent academic physicians, will receive a $75,000 grant over a two-year period. The award must be matched by support (either from the applicant’s home institution or a grant-making agency) that provides for 75% protected time for research. Research findings are presented at the American Geriatrics Society Annual Scientific Meeting at the conclusion of the recipient’s grant.